HTR1B (GeneName), 5-hydroxytryptamine receptor 1B (ProteinName), 5HT1B_CANLF.
Product Name:
Dog HTR1B/ 5-hydroxytryptamine receptor 1B ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
5-HT-1B, 5-HT1D subtype beta, Serotonin receptor 1B
Detection Method:
ELISA
Specificity:
Natural and recombinant dog 5-hydroxytryptamine receptor 1B
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Homodimer. Heterodimer with HTR1D.
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Lack of association between five serotonin metabolism-related genes and medication overuse headache."
[2].
"[Association study of HTR1A and HTR1B with adolescent idiopathic scoliosis]."
[3].
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."
[4].
"Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder."
[5].
"Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men."
[7].
"An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population."
[8].
"Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder."
[9].
"The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence."
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