HTR1A (GeneName), 5-hydroxytryptamine receptor 1A (ProteinName), 5HT1A_CANLF.
Product Name:
Dog HTR1A/ 5-hydroxytryptamine receptor 1A ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
5-HT-1A, Serotonin receptor 1A
Detection Method:
ELISA
Specificity:
Natural and recombinant dog 5-hydroxytryptamine receptor 1A
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Heterodimer; heterodimerizes with GPER1.
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."
[3].
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."
[4].
"Interaction between genetic polymorphisms and stressful life events in first episode depression."
[5].
"Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression."
[6].
"Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes."
[7].
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."
[8].
"Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia."
[9].
"Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders."
[10].
"Association between 5-hydroxytryptamine 1A receptor gene polymorphism and suicidal behavior."
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