EIF4ENIF1 (GeneName), Eukaryotic translation initiation factor 4E transporter (ProteinName), 4ET_HUMAN.
Product Name:
Human EIF4ENIF1/ Eukaryotic translation initiation factor 4E transporter ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
4E-T, Eukaryotic translation initiation factor 4E nuclear import factor 1
Detection Method:
ELISA
Specificity:
Natural and recombinant human Eukaryotic translation initiation factor 4E transporter
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.
Function:
Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.
Subcellular Location:
Cytoplasm
Nucleus
Nucleus
PML body
Nucleus speckle
Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.
This product has not yet been referenced specifically in any publications.
[1].
"A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E."
[2].
"The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G."
[3].
"Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation."
[4].
"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."
[5].
"A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay."
[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[9].
"Architecture of the human interactome defines protein communities and disease networks."
[10].
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."
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