Home > ELISA Kit > Human EIF4ENIF1 ELISA Kit

EIF4ENIF1 (GeneName), Eukaryotic translation initiation factor 4E transporter (ProteinName), 4ET_HUMAN.

Product Name:

Human EIF4ENIF1/ Eukaryotic translation initiation factor 4E transporter ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

4E-T, Eukaryotic translation initiation factor 4E nuclear import factor 1

Detection Method:

ELISA

Specificity:

Natural and recombinant human Eukaryotic translation initiation factor 4E transporter

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Size & Price: Sign In.

Attention

Human EIF4ENIF1 ELISA Kit

Email *

Message *

Please Sign In.

Product Datasheets

Data
Citations
Publication
Sequence / 3D
Feedback Wall (0)

General Annotation

Sub Unit:

Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.

Function:

Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Subcellular Location:

Cytoplasm Nucleus Nucleus PML body Nucleus speckle Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.

Database link

UniGene:

Hs.517559

SMR:

Q9NRA8

STRING:

9606.ENSP00000328103

KEGG:

hsa:56478

MIM:

607445

Pfam:

PF10477

Uniprot:

Q9NRA8

Related Product

Human C19orf80 ELISA Kit

Mouse Trap1a ELISA Kit

Human ASPRO ELISA Kit

Human GDF5 ELISA Kit

Human ACE ELISA Kit

Sequence length:

985

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

985:

SPVGLAKWFG | SDVLQQPLPS | MPAKVISVDE | LEYRQ

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E."

(PMID: 10856257)

[2].

"The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G."

(PMID: 19850929)

[3].

"Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation."

(PMID: 16343815)

[4].

"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."

(PMID: 16699599)

[5].

"A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay."

(PMID: 16157702)

[6].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[7].

"A genome annotation-driven approach to cloning the human ORFeome."