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EIF4ENIF1 (GeneName), Eukaryotic translation initiation factor 4E transporter (ProteinName), 4ET_HUMAN.
Product Name:

Human EIF4ENIF1/ Eukaryotic translation initiation factor 4E transporter ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

4E-T, Eukaryotic translation initiation factor 4E nuclear import factor 1

Detection Method:
ELISA
Specificity:
Natural and recombinant human Eukaryotic translation initiation factor 4E transporter
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human EIF4ENIF1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.


Function:
Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.


Subcellular Location:
Cytoplasm Nucleus Nucleus PML body Nucleus speckle Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.


This product has not yet been referenced specifically in any publications.

[1].
"A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E."

[2].
"The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G."

[3].
"Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation."

[4].
"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."

[5].
"A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay."

[6].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[7].
"A genome annotation-driven approach to cloning the human ORFeome."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."
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