Eif4ebp1 (基因名), Eukaryotic translation initiation factor 4E-binding protein 1 (蛋白名), 4EBP1_RAT.
Rat Eif4ebp1/ Eukaryotic translation initiation factor 4E-binding protein 1 ELISA Kit
4E-BP1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I
Natural and recombinant rat Eukaryotic translation initiation factor 4E-binding protein 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7939721). Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1.
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7939721).
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