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EPB41 (GeneName), Erythroid protein 4.1 (ProteinName), 41_CHICK.
Product Name:

Chicken EPB41/ Erythroid protein 4.1 ELISA Kit

Cat.#:

E11605c

Brand:
EIAab®
Regulatory Status:
Alternative:

Band 4.1

Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Erythroid protein 4.1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Chicken EPB41 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin and DLG1.


Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. May be required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.


Subcellular Location:
Nucleus Cytoplasm Cytoskeleton Cytoplasm Cell cortex


This product has not yet been referenced specifically in any publications.

[1].
"An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R."

[2].
"Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization."

[3].
"Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase."

[4].
"Identification of SNP markers on 1p36 and association analysis of EPB41 with mandibular prognathism in a Chinese population."

[5].
"Marked difference in membrane-protein-binding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation."
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