Mpg (GeneName), DNA-3-methyladenine glycosylase (ProteinName), 3MG_RAT.
Product Name:
Rat Mpg/ DNA-3-methyladenine glycosylase ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, ADPG, N-methylpurine-DNA glycosylase
Detection Method:
ELISA
Specificity:
Natural and recombinant rat DNA-3-methyladenine glycosylase
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Binds MBD1. Binds SSBP1.
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Subcellular Location:
Cytoplasm
Mitochondrion matrix
Mitochondrion nucleoid
Nucleus
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase."
[2].
"Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin."
[3].
"Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision."
[4].
"Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse."
[5].
"Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere."
[6].
"Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16."
[7].
"Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)."
[8].
"Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein."
[9].
"Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations."
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