Sh3bp5 (GeneName), SH3 domain-binding protein 5 (ProteinName), 3BP5_RAT.
Rat Sh3bp5/ SH3 domain-binding protein 5 ELISA Kit
SH3BP-5, Vascular endothelial cell-specific protein 18, Sab, Vesp18
Natural and recombinant rat SH3 domain-binding protein 5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with BTK (PubMed:15158451). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:15158451). Interacts with GDP-bound and nucleotide-free forms of RAB11A.
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
MDTALKRSRS | EEPVELPPPA | REAEEKEEEE | ERMEQGLEEE | EEVDPRIQGE |
LEKLNQSTDD | INRRETELED | ARQKFRSVLV | EATVKLDELA | KKIGKAVEDS |
KPYWEARRVA | RQAQLEAQKA | TQDFQRATEV | LRAAKETISL | AEQRLLEDDK |
RQFDSAWQEM | LNHATQRVME | AEQTKTRSEL | VHKETAARYN | AAMGRMRQLE |
KKLKRAINKS | KPYFELKAKY | YVQLEQLKKT | VDDLQAKLAL | AKGEYKAALK |
SLERISDEIH | ERRRSNAMGP | RGCGVGAEGS | ITSVENLPAS | KPEPDAISVA |
SEAFEDDNCG | NLVSEDDSET | QSVSSFSSGP | TSPSEMPDQF | PAVARPGSLD |
LPSPVSLSEF | GMMFPILGPR | SECSGASSPE | CEVERGDRAE | GAENKMSDKA |
NNNRVLSSTS | AGGGRSRSQS | STSLEGQALE | TRMKQLSLQC | SKGREGIIAD |
This product has not yet been referenced specifically in any publications.
"Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."
"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)."
"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5."
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein."
"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."
"Architecture of the human interactome defines protein communities and disease networks."
"REI/SH3BP5 protein family: New GEFs for Rab11."
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