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Sh3bp5 (GeneName), SH3 domain-binding protein 5 (ProteinName), 3BP5_RAT.
Product Name:

Rat Sh3bp5/ SH3 domain-binding protein 5 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

SH3BP-5, Vascular endothelial cell-specific protein 18, Sab, Vesp18

Detection Method:
ELISA
Specificity:
Natural and recombinant rat SH3 domain-binding protein 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat Sh3bp5 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with BTK (PubMed:15158451). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:15158451). Interacts with GDP-bound and nucleotide-free forms of RAB11A.


Function:
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.


Subcellular Location:
Mitochondrion


This product has not yet been referenced specifically in any publications.

[1].
"Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."

[2].
"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)."

[3].
"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5."

[4].
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein."

[8].
"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"REI/SH3BP5 protein family: New GEFs for Rab11."
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