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SH3BP5 (GeneName), SH3 domain-binding protein 5 (ProteinName), 3BP5_HUMAN.

Product Name:

Human SH3BP5/ SH3 domain-binding protein 5 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SAB

Detection Method:

ELISA

Specificity:

Natural and recombinant human SH3 domain-binding protein 5

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Human SH3BP5 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).

Function:

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Subcellular Location:

Mitochondrion

Database link

UniGene:

Hs.257761

SMR:

O60239

STRING:

9606.ENSP00000373301

KEGG:

hsa:9467

MIM:

605612

Pfam:

PF05276

Uniprot:

O60239

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Sequence length:

455

Sequence:

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455:

MVQIG

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."

(PMID: 10339589)

[2].

"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)."

(PMID: 9571151)

[3].

"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5."

(PMID: 30217979)

[4].

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."

(PMID: 16964243)

[5].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[6].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."