SH3BP5 (GeneName), SH3 domain-binding protein 5 (ProteinName), 3BP5_HUMAN.
Human SH3BP5/ SH3 domain-binding protein 5 ELISA Kit
SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SAB
Natural and recombinant human SH3 domain-binding protein 5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
MDAALKRSRS | EEPAEILPPA | RDEEEEEEEG | MEQGLEEEEE | VDPRIQGELE |
KLNQSTDDIN | RRETELEDAR | QKFRSVLVEA | TVKLDELVKK | IGKAVEDSKP |
YWEARRVARQ | AQLEAQKATQ | DFQRATEVLR | AAKETISLAE | QRLLEDDKRQ |
FDSAWQEMLN | HATQRVMEAE | QTKTRSELVH | KETAARYNAA | MGRMRQLEKK |
LKRAINKSKP | YFELKAKYYV | QLEQLKKTVD | DLQAKLTLAK | GEYKMALKNL |
EMISDEIHER | RRSSAMGPRG | CGVGAEGSST | SVEDLPGSKP | EPDAISVASE |
AFEDDSCSNF | VSEDDSETQS | VSSFSSGPTS | PSEMPDQFPA | VVRPGSLDLP |
SPVSLSEFGM | MFPVLGPRSE | CSGASSPECE | VERGDRAEGA | ENKTSDKANN |
NRGLSSSSGS | GGSSKSQSST | SPEGQALENR | MKQLSLQCSK | GRDGIIADIK |
This product has not yet been referenced specifically in any publications.
"Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."
"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)."
"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5."
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein."
"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."
"Architecture of the human interactome defines protein communities and disease networks."
"REI/SH3BP5 protein family: New GEFs for Rab11."
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