SH3BP5 (GeneName), SH3 domain-binding protein 5 (ProteinName), 3BP5_HUMAN.
Product Name:
Human SH3BP5/ SH3 domain-binding protein 5 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SAB
Detection Method:
ELISA
Specificity:
Natural and recombinant human SH3 domain-binding protein 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).
Function:
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Subcellular Location:
Mitochondrion
This product has not yet been referenced specifically in any publications.
[1].
"Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."
[2].
"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)."
[3].
"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5."
[4].
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[8].
"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."
[9].
"Architecture of the human interactome defines protein communities and disease networks."
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