Sh3bp1 (GeneName), SH3 domain-binding protein 1 (ProteinName), 3BP1_MOUSE.
Mouse Sh3bp1/ SH3 domain-binding protein 1 ELISA Kit
Natural and recombinant mouse SH3 domain-binding protein 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
MAESFKELDP | DSSMGKALEM | TCAIQNQLAR | ILAEFEMTLE | RDVLQPLSRL |
SEEELPAILK | HKKSLQKLVS | DWNTLKSRLS | QAAKNSGSNQ | GLGGASGSHT |
HTTTANKVEM | LKEEEEELKK | KVEQCKDEYL | ADLYHFSTKE | DSYANYFIHL |
LEIQADYHRK | SLTSLDTALA | ELRDNHSQAD | HSPLTTAAPF | SRVYGVSLRT |
HLQDLGRDIA | LPIEACVLLL | LSEGMQEEEG | LFRLAAGASV | LKRLKQTMAS |
DPHSLEEFCS | DPHAVAGALK | SYLRELPEPL | MTSDLYDDWM | RAASLKEPGA |
RLEALHDVCS | RLPQENFNNL | RYLMKFLALL | AEEQDVNKMT | PSNIAIVLGP |
NLLWPPEKEG | DQAQLDAASV | SSIQVVGVVE | ALIQNADTLF | PGDINFNVSG |
IFPGLAPQEK | VSSQQVSEEL | PPVTVPAPAT | TPAPTPAPAS | MAVRERTEAD |
LPKPTSPKVS | RNPTETAASA | EDMTRKTKRP | APARPTMPPP | QPSSTRSSPP |
APSLPPGSVS | PGTPQALPRR | LVGTSLRAPT | MPPPLPPVPP | QPARRQSRRL |
PASPVISNMP | AQVDQGVATE | DRGGPEAVGG | HPPPPALPPQ | PRPRGLISET |
This product has not yet been referenced specifically in any publications.
"The DNA sequence of human chromosome 22."
"Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins."
"An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling."
"A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation."
"Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex."
"SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"A genome annotation-driven approach to cloning the human ORFeome."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1."
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