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Hsd3b7 (GeneName), 3 beta-hydroxysteroid dehydrogenase type 7 (ProteinName), 3BHS7_MOUSE.
Product Name:

Mouse Hsd3b7/ 3 beta-hydroxysteroid dehydrogenase type 7 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-HSD VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, C(27) 3-beta-HSD, Cholest-5-ene-3-beta, 7-alpha-diol 3-beta-dehydrogenase

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse 3 beta-hydroxysteroid dehydrogenase type 7
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Hsd3b7 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953).


Subcellular Location:
Endoplasmic reticulum membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease."

[2].
"The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis."

[3].
"The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Novel Mutations in the 3β-hydroxy-?5-C27-steroid Dehydrogenase Gene (HSD3B7) in a Patient with Neonatal Cholestasis."

[7].
"Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome."

[8].
"A proteome-scale map of the human interactome network."

[9].
"Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology."

[10].
"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
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