HSD3B7 (GeneName), 3 beta-hydroxysteroid dehydrogenase type 7 (ProteinName), 3BHS7_HUMAN.
Product Name:
Human HSD3B7/ 3 beta-hydroxysteroid dehydrogenase type 7 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-HSD VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, C(27) 3-beta-HSD, Cholest-5-ene-3-beta, 7-alpha-diol 3-beta-dehydrogenase
Detection Method:
ELISA
Specificity:
Natural and recombinant human 3 beta-hydroxysteroid dehydrogenase type 7
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
This product has not yet been referenced specifically in any publications.
[1].
"Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease."
[2].
"The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis."
[3].
"The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative."
[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[6].
"Novel Mutations in the 3β-hydroxy-?5-C27-steroid Dehydrogenase Gene (HSD3B7) in a Patient with Neonatal Cholestasis."
[7].
"Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome."
[9].
"Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology."
[10].
"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
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