HSD3B7 (GeneName), 3 beta-hydroxysteroid dehydrogenase type 7 (ProteinName), 3BHS7_HUMAN.
Human HSD3B7/ 3 beta-hydroxysteroid dehydrogenase type 7 ELISA Kit
3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-HSD VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, C(27) 3-beta-HSD, Cholest-5-ene-3-beta, 7-alpha-diol 3-beta-dehydrogenase
Natural and recombinant human 3 beta-hydroxysteroid dehydrogenase type 7
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Endoplasmic reticulum membrane Multi-pass membrane protein
MADSAQAQKL | VYLVTGGCGF | LGEHVVRMLL | QREPRLGELR | VFDQHLGPWL |
EELKTGPVRV | TAIQGDVTQA | HEVAAAVAGA | HVVIHTAGLV | DVFGRASPKT |
IHEVNVQGTR | NVIEACVQTG | TRFLVYTSSM | EVVGPNTKGH | PFYRGNEDTP |
YEAVHRHPYP | CSKALAEWLV | LEANGRKVRG | GLPLVTCALR | PTGIYGEGHQ |
IMRDFYRQGL | RLGGWLFRAI | PASVEHGRVY | VGNVAWMHVL | AARELEQRAT |
LMGGQVYFCY | DGSPYRSYED | FNMEFLGPCG | LRLVGARPLL | PYWLLVFLAA |
LNALLQWLLR | PLVLYAPLLN | PYTLAVANTT | FTVSTDKAQR | HFGYEPLFSW |
EDSRTRTILW | VQAATGSAQ
This product has not yet been referenced specifically in any publications.
"Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease."
"The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis."
"The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Novel Mutations in the 3β-hydroxy-?5-C27-steroid Dehydrogenase Gene (HSD3B7) in a Patient with Neonatal Cholestasis."
"Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome."
"A proteome-scale map of the human interactome network."
"Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology."
"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
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