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Hsd3b2 (GeneName), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (ProteinName), 3BHS2_MOUSE.

Product Name:

Mouse Hsd3b2/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, 3-beta-HSD II

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Mouse Hsd3b2 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

N/A

Function:

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein

Database link

UniGene:

Mm.482364

STRING:

10090.ENSMUSP00000102635

KEGG:

mmu:15493

Pfam:

PF01073

Uniprot:

P26149

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Sequence length:

373

Sequence:

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373:

QKTSEWIGTL | VEQHRETLDT | KSQ

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer."

(PMID: 19505920)

[2].

"Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia."

(PMID: 18252794)

[3].

"Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer."

(PMID: 17507624)

[4].

"Variant in sex hormone-binding globulin gene and the risk of prostate cancer."

(PMID: 17220347)

[5].

"SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness."

(PMID: 17823934)

[6].

"Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping."

(PMID: 15585552)

[7].

"The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."

(PMID: 14764797)

[8].

"Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias."

(PMID: 14764821)

[9].

"Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility."

(PMID: 11912155)

[10].

"Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls."

(PMID: 10651755)

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