PPP2R2D (GeneName), Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (ProteinName), 2ABD_HUMAN.
Human PPP2R2D/ Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform ELISA Kit
PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta, KIAA1541
Natural and recombinant human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Interacts with IER5 (PubMed:25816751).
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.
MAGAGGGGCP | AGGNDFQWCF | SQVKGAIDED | VAEADIISTV | EFNYSGDLLA |
TGDKGGRVVI | FQREQENKSR | PHSRGEYNVY | STFQSHEPEF | DYLKSLEIEE |
KINKIRWLPQ | QNAAHFLLST | NDKTIKLWKI | SERDKRAEGY | NLKDEDGRLR |
DPFRITALRV | PILKPMDLMV | EASPRRIFAN | AHTYHINSIS | VNSDHETYLS |
ADDLRINLWH | LEITDRSFNI | VDIKPANMEE | LTEVITAAEF | HPHQCNVFVY |
SSSKGTIRLC | DMRSSALCDR | HSKFFEEPED | PSSRSFFSEI | ISSISDVKFS |
HSGRYMMTRD | YLSVKVWDLN | MESRPVETHQ | VHEYLRSKLC | SLYENDCIFD |
KFECCWNGSD | SAIMTGSYNN | FFRMFDRDTR | RDVTLEASRE | SSKPRASLKP |
RKVCTGGKRR | KDEISVDSLD | FNKKILHTAW | HPVDNVIAVA | ATNNLYIFQD |
This product has not yet been referenced specifically in any publications.
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