Home > ELISA Kit > Human PPP2R2D ELISA Kit

PPP2R2D (GeneName), Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (ProteinName), 2ABD_HUMAN.

Product Name:

Human PPP2R2D/ Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta, KIAA1541

Detection Method:

ELISA

Specificity:

Natural and recombinant human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Human PPP2R2D ELISA Kit

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Product Datasheets

Data
Citations
Sequence / 3D
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General Annotation

Sub Unit:

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Interacts with IER5 (PubMed:25816751).

Function:

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subcellular Location:

Cytoplasm

Database link

UniGene:

Hs.380372

SMR:

Q66LE6

STRING:

9606.ENSP00000399970

KEGG:

hsa:55844

MIM: