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Ppp2r2b (GeneName), Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (ProteinName), 2ABB_MOUSE.

Product Name:

Mouse Ppp2r2b/ Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

PP2A subunit B isoform B55-beta, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Cancer

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Mouse Ppp2r2b ELISA Kit

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Product Datasheets

Data
Citations
Sequence / 3D
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General Annotation

Sub Unit:

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions).

Function:

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.

Subcellular Location:

Isoform 2 Cytoplasm Mitochondrion Mitochondrion outer membrane Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity).

Database link

UniGene:

Mm.26134

SMR:

Q6ZWR4

STRING:

10090.ENSMUSP00000025377

KEGG:

mmu:72930

Uniprot:

Q6ZWR4

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