PPP2R1A (GeneName), Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (ProteinName), 2AAA_BOVIN.
Product Name:
Bovine PPP2R1A/ Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
- Data
- Citations
- Sequence / 3D
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General Annotation
Sub Unit:
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGO1 (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with PLA2G16; this interaction might decrease PP2A activity. Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites (By similarity). Interacts with CTTNBP2NL.
Function:
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
Subcellular Location:
Chromosome
Centromere
Cytoplasm
Centromeric localization requires the presence of BUB1.
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
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