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Ppp2r5c (GeneName), Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (ProteinName), 2A5G_MOUSE.
Product Name:

Mouse Ppp2r5c/ Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

PP2A B subunit isoform B'-alpha-3, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Ppp2r5c ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with SGO1; the interaction is direct. May interact with TP53 (By similarity). Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation.


Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.


Subcellular Location:
Nucleus Chromosome Centromere


This product has not yet been referenced specifically in any publications.
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