PPP2R5C (GeneName), Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (ProteinName), 2A5G_HUMAN.
Human PPP2R5C/ Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform ELISA Kit
PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, KIAA0044
Natural and recombinant human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGO1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Nucleus Chromosome Centromere
MLTCNKAGSR | MVVDAANSNG | PFQPVVLLHI | RDVPPADQEK | LFIQKLRQCC |
VLFDFVSDPL | SDLKWKEVKR | AALSEMVEYI | THNRNVITEP | IYPEVVHMFA |
VNMFRTLPPS | SNPTGAEFDP | EEDEPTLEAA | WPHLQLVYEF | FLRFLESPDF |
QPNIAKKYID | QKFVLQLLEL | FDSEDPRERD | FLKTTLHRIY | GKFLGLRAYI |
RKQINNIFYR | FIYETEHHNG | IAELLEILGS | IINGFALPLK | EEHKIFLLKV |
LLPLHKVKSL | SVYHPQLAYC | VVQFLEKDST | LTEPVVMALL | KYWPKTHSPK |
EVMFLNELEE | ILDVIEPSEF | VKIMEPLFRQ | LAKCVSSPHF | QVAERALYYW |
NNEYIMSLIS | DNAAKILPIM | FPSLYRNSKT | HWNKTIHGLI | YNALKLFMEM |
NQKLFDDCTQ | QFKAEKLKEK | LKMKEREEAW | VKIENLAKAN | PQYTVYSQAS |
TMSIPVAMET | DGPLFEDVQM | LRKTVKDEAH | QAQKDPKKDR | PLARRKSELP |
QDPHTKKALE | AHCRADELAS | QDGR
This product has not yet been referenced specifically in any publications.
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