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Ppp2r5b (GeneName), Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (ProteinName), 2A5B_RAT.

Product Name:

Rat Ppp2r5b/ Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta, LOC100909468, rCG_47223

Detection Method:

ELISA

Specificity:

Natural and recombinant rat Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Rat Ppp2r5b ELISA Kit

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Product Datasheets

Data
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Sequence / 3D
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General Annotation

Sub Unit:

Component of the serine/threonine-protein phosphatase 2A complex (PP2A). This complex consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant scaffold subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1. Interacts with AKT1.

Function:

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.

Subcellular Location:

Cytoplasm

Database link

UniGene:

Rn.40996

SMR:

Q80W83

STRING:

10116.ENSRNOP00000065720

KEGG:

rno:309179

Pfam: