YWHAZ (GeneName), 14-3-3 protein zeta/delta (ProteinName), 1433Z_BOVIN.
Bovine YWHAZ/ 14-3-3 protein zeta/delta ELISA Kit
Factor activating exoenzyme S, FAS, Protein kinase C inhibitor protein 1, KCIP-1
Natural and recombinant bovine 14-3-3 protein zeta/delta
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 ARHGEF2, CDK16 and BSPRY. Interacts with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation (By similarity). Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2. Interacts with BCL2L11, SAMSN1 and TLK2 (By similarity). Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with Thr-phosphorylated ITGB2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin.
Cytoplasm Melanosome Located to stage I to stage IV melanosomes.
MDKNELVQKA | KLAEQAERYD | DMAACMKSVT | EQGAELSNEE | RNLLSVAYKN |
VVGARRSSWR | VVSSIEQKTE | GAEKKQQMAR | EYREKIETEL | RDICNDVLSL |
LEKFLIPNAS | QAESKVFYLK | MKGDYYRYLA | EVAAGDDKKG | IVDQSQQAYQ |
EAFEISKKEM | QPTHPIRLGL | ALNFSVFYYE | ILNSPEKACS | LAKTAFDEAI |
AELDTLSEES | YKDSTLIMQL | LRDNLTLWTS | DTQGDEAEAG | EGGEN
This product has not yet been referenced specifically in any publications.
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Examination of association of genes in the serotonin system to autism."
"Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study."
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
"14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk."
"Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk."
"Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon."
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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