SFN (GeneName), 14-3-3 protein sigma (ProteinName), 1433S_BOVIN.
Bovine SFN/ 14-3-3 protein sigma ELISA Kit
Natural and recombinant bovine 14-3-3 protein sigma
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with KRT17. Interacts with GAB2 and SAMSN1 (By similarity). Interacts with SRPK2 (By similarity). Interacts with COPS6 (By similarity). Interacts with RFWD2; this interaction leads to proteasomal degradation (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB (By similarity). Interacts with SLITRK1.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Cytoplasm Nucleus Secreted May be secreted by a non-classical secretory pathway.
MERASLIQKA | KLAEQAERYE | DMAAFMKSAV | EKGEELSCEE | RNLLSVAYKN |
VVGGQRAAWR | VLSSIEQKSN | EESSEEKGPE | VQEYREKVET | ELRGVCDTVL |
GLLDTHLIKE | AGDAESRVFY | LKMKGDYYRY | LAEVATGDDK | KRIIDSARSA |
YQEAMDISKK | EMPPTNPIRL | GLALNFSVFH | YEIANSPEEA | ISLAKTTFDE |
AMADLHTLSE | DSYKDSTLIM | QLLRDNLTLW | TADNAGEEGG | EAPEEPQS
This product has not yet been referenced specifically in any publications.
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