SFN (GeneName), 14-3-3 protein sigma (ProteinName), 1433S_BOVIN.
Product Name:
Bovine SFN/ 14-3-3 protein sigma ELISA Kit
Cat.#:
E15106b
Brand:
EIAab®
Regulatory Status:
Alternative:
Stratifin
Detection Method:
ELISA
Assay Type:
Sandwich
Specificity:
Natural and recombinant bovine 14-3-3 protein sigma
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
Cancer
Product Overview:
E15106b is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay)
Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (14-3-3 protein sigma) ELISA Kit target analytes in biological samples. The concentration gradients of
the kit standards or positive controls render a theoretical kit detection range in biological research samples containing 14-3-3 protein sigma. The ELISA analytical biochemical
technique of the E15106b kit is based on 14-3-3 protein sigma antibody-14-3-3 protein sigma antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect 14-3-3 protein sigma
antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, 14-3-3 protein sigma. Appropriate sample types may include undiluted human body fluids
and/or tissue homogenates,
secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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General Annotation
Sub Unit:
Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with KRT17. Interacts with GAB2 and SAMSN1 (By similarity). Interacts with SRPK2 (By similarity). Interacts with COPS6 (By similarity). Interacts with RFWD2; this interaction leads to proteasomal degradation (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB (By similarity). Interacts with SLITRK1.
Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Subcellular Location:
Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.
Database links
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Vaild Sequence:
This product has not yet been referenced specifically in any publications.
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