Ywhag (基因名), 14-3-3 protein gamma (蛋白名), 1433G_MOUSE.
Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with PKA-phosphorylated AANAT and SIRT2 (By similarity). Interacts with SAMSN1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
MVDREQLVQK | ARLAEQAERY | DDMAAAMKNV | TELNEPLSNE | ERNLLSVAYK |
NVVGARRSSW | RVISSIEQKT | SADGNEKKIE | MVRAYREKIE | KELEAVCQDV |
LSLLDNYLIK | NCSETQYESK | VFYLKMKGDY | YRYLAEVATG | EKRATVVESS |
EKAYSEAHEI | SKEHMQPTHP | IRLGLALNYS | VFYYEIQNAP | EQACHLAKTA |
FDDAIAELDT | LNEDSYKDST | LIMQLLRDNL | TLWTSDQQDD | DGGEGNN
"Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23."
"14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells."
"De Novo Mutations in YWHAG Cause Early-Onset Epilepsy."
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Centrosome-related genes, genetic variation, and risk of breast cancer."
"Genome-wide association study of severity in multiple sclerosis."
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
"Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics."
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
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