YWHAG (GeneName), 14-3-3 protein gamma (ProteinName), 1433G_HUMAN.
Product Name:
Human YWHAG/ 14-3-3 protein gamma ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Protein kinase C inhibitor protein 1, KCIP-1
Detection Method:
ELISA
Specificity:
Natural and recombinant human 14-3-3 protein gamma
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT and SIRT2.Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).
Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular Location:
Cytoplasm
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23."
[2].
"14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells."
[4].
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
[7].
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
[8].
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
[9].
"Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics."
[10].
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
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