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Ywhae (GeneName), 14-3-3 protein epsilon (ProteinName), 1433E_MOUSE.
Product Name:

Mouse Ywhae/ 14-3-3 protein epsilon ELISA Kit

Regulatory Status:


Detection Method:
Natural and recombinant mouse 14-3-3 protein epsilon
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Product Overview:
is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (14-3-3 protein epsilon) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing 14-3-3 protein epsilon. The ELISA analytical biochemical technique of the kit is based on 14-3-3 protein epsilon antibody-14-3-3 protein epsilon antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect 14-3-3 protein epsilon antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, 14-3-3 protein epsilon. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Mouse Ywhae ELISA Kit
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Mouse Ywhae ELISA Kit
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Product Datasheets

General Annotation

Sub Unit:
Homodimer (By similarity). Heterodimerizes with YWHAZ (By similarity). Interacts with PKA-phosphorylated AANAT (By similarity). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with ARHGEF28 (PubMed:11533041). Interacts with BEX3 (PubMed:11278287). Weakly interacts with CDKN1B (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with DENND1A (By similarity). Interacts with GAB2 (By similarity). Interacts with phosphorylated GRB10 (PubMed:15722337). Interacts with KSR1 (PubMed:10409742). Interacts with NDEL1 (PubMed:12796778). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with the phosphorylated (by AKT1) form of SRPK2 (By similarity). Interacts with TIAM2 (PubMed:17320046). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts with ZFP36 (via phosphorylated form) (PubMed:21078877). Interacts with SLITRK1 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner.

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.

Subcellular Location:
Nucleus Cytoplasm Melanosome

This product has not yet been referenced specifically in any publications.
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"KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing."

"Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils."

"Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins."

"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."

"Centrosome-related genes, genetic variation, and risk of breast cancer."

"Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia."

"Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis."

"Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications that show distinctive phenotypes."

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."

"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
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