YWHAE (基因名), 14-3-3 protein epsilon (蛋白名), 1433E_HUMAN.
(Microbial infection) Interacts with HCV core protein.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
Nucleus Cytoplasm Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
MDDREDLVYQ | AKLAEQAERY | DEMVESMKKV | AGMDVELTVE | ERNLLSVAYK |
NVIGARRASW | RIISSIEQKE | ENKGGEDKLK | MIREYRQMVE | TELKLICCDI |
LDVLDKHLIP | AANTGESKVF | YYKMKGDYHR | YLAEFATGND | RKEAAENSLV |
AYKAASDIAM | TELPPTHPIR | LGLALNFSVF | YYEILNSPDR | ACRLAKAAFD |
DAIAELDTLS | EESYKDSTLI | MQLLRDNLTL | WTSDMQGDGE | EQNKEALQDV |
"KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing."
"Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils."
"Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins."
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Centrosome-related genes, genetic variation, and risk of breast cancer."
"Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia."
"Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis."
"Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications that show distinctive phenotypes."
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
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