YWHAE (基因名), 14-3-3 protein epsilon (蛋白名), 1433E_BOVIN.
Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, ARHGEF28 and TIAM2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10. Interacts with PKA-phosphorylated AANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with KSR1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with DENND1A (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with TIAM2. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1. Interacts with ZFP36 (via phosphorylated form) (By similarity). Interacts with SLITRK1 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346). Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.
Nucleus Cytoplasm Melanosome
MDDREDLVYQ | AKLAEQAERY | DEMVESMKKV | AGMDVELTVE | ERNLLSVAYK |
NVIGARRASW | RIISSIEQKE | ENKGGEDKLK | MIREYRQMVE | TELKLICCDI |
LDVLDKHLIP | AANTGESKVF | YYKMKGDYHR | YLAEFATGND | RKEAAENSLV |
AYKAASDIAM | TELPPTHPIR | LGLALNFSVF | YYEILNSPDR | ACRLAKAAFD |
DAIAELDTLS | EESYKDSTLI | MQLLRDNLTL | WTSDMQGDGE | EQNKEALQDV |
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