ASPRO (Shorten Name ),
Human ASPRO/ Asprosin ELISA Kit
Natural and recombinant human Asprosin
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
E15190-1h is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Asprosin) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Asprosin. The ELISA analytical biochemical technique of the E15190-1h kit is based on Asprosin antibody-Asprosin antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Asprosin antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Asprosin. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Asprosin, a fasting-induced glucogenic protein homone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and encoded by the ultimate two exons of FBN1.
Circulating asprosin, a protein hormone, responds to low dietary glucose by triggering the release of liver glucose stores, and the reduction of asprosin protects against the hyperinsulinism associated with metabolic syndrome.
Asprosin circulates at nanomolar levels, a single dose of recombinant asprosin retains biological activity and elevates blood glucose and insulin levels. Liver is the target organ for asprosin to recruit. Asprosin increases hepatocyte glucose release through activating the G protein-cAMP-PKA pathway.
This product has not yet been referenced specifically in any publications.
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