DCP (Shorten Name ),
Product Name:
Human DCP/ Des-gamma carboxyprothrombin ELISA Kit
Cat.#:
E2181h
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/mL
Sensitivity:
0.15ng/mL
Specificity:
Natural and recombinant human Des-gamma carboxyprothrombin
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:

Research Area:
-
- Data
- Citations ( 2 )
- Sequence / 3D
- Feedback Wall (0)
Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤5.3%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤8.1%
Recovery
Recovery was determined by spiking various levels of Des-gamma carboxyprothrombin into serum and plasma.
Sample Type |
Average(%) |
Recovery Range(%) |
Serum |
102 |
96-108 |
Plasma |
104 |
98-110 |
Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Des-gamma carboxyprothrombin and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
Sample |
1:2 |
1:4 |
1:8 |
1:16 |
serum(n=5) |
101-114% |
97-107% |
102-112% |
104-113% |
EDTA plasma(n=5) |
88-98% |
93-102% |
90-102% |
102-112% |
heparin plasma(n=5) |
90-99%
|
95-104% |
97-107% |
92-102% |
General Annotation
Sub Unit:
N/A
Function:
Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K.
Location:
N/A
[2].
Abdel-Razik A, Elhelaly R, Elzehery R, et al.
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