General NA/ Noradrenaline ELISA Kit

Cat.#:

E0907Ge

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

NE, Norepinephrine, Isoprenaline

Detection Method:

ELISA

Assay Type:

Competitive

Detection Range:

31.2-2000pg/mL

Sensitivity:

9.8pg/mL

Specificity:

Natural and recombinant general Noradrenaline

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

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General NA ELISA Kit

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Product Datasheets

Datasheet:

Instruction:

MSDS:

Data
Citations ( 2 )
Sequence / 3D
Feedback Wall (0)

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Noradrenaline and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	82-92%	80-90%	86-96%	98-108%
EDTA plasma(n=5)	90-103%	110-118%	98-110%	84-96%
heparin plasma(n=5)	84-94%	87-97%	92-101%	104-114%

General Annotation

Sub Unit:

N/A

Function:

One of the most important functions of Noradrenaline is its role as the neurotransmitter released from the sympathetic neurons affecting the heart. An increase in Noradrenaline from the sympathetic nervous system increases the rate of contractions. When Noradrenaline acts as a drug, it increases blood pressure by increasing vascular tone (tension of vascular smooth muscle) through α-adrenergic receptor activation; a reflex bradycardia homeostatic baroreflex is overcome by a compensatory reflex preventing an otherwise inevitable drop in heart rate to maintain blood pressure.

Location:

Noradrenaline is synthesized from dopamine by dopamine β-hydroxylase.[8] It is released from the adrenal medulla into the blood as a hormone, and is also a neurotransmitter in the central nervous system and sympathetic nervous system, where it is released from noradrenergic neurons in the locus coeruleus. The actions of norepinephrine are carried out via the binding to adrenergic receptors.

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