T3 (Shorten Name ),
General T3/ Triiodothyronine ELISA Kit
Natural and recombinant general Triiodothyronine
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
E0453Ge is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Triiodothyronine) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Triiodothyronine. The ELISA analytical biochemical technique of the E0453Ge kit is based on Triiodothyronine antibody-Triiodothyronine antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Triiodothyronine antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Triiodothyronine. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Triiodothyronine and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
The T3 (and T4) bind to nuclear receptors, thyroid receptors. T3 (and T4) are very lipophilic and able to pass through the phospholipid bilayers of target cells. The lipophilicity of T3 (and T4) requires their binding to the protein carrier thyroid-binding protein (TBG) [thyroxine-binding globulins, thyroxine binding prealbumins, and albumins] for transport in the blood. The thyroid receptors bind to response elements in gene promoters, thus enabling them to activate or inhibit transcription. The sensitivity of a tissue to T3 is modulated through the thyroid receptors.
"Parental exposure to tebuconazole causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring"
SY Li, Q Wu, S Coffin, et al.
"Perfluorooctane sulfonic acid exposure increases cadmium toxicity in early life stage of zebrafish, Danio rerio"
Suyoung Kim, Kyunghee Ji, Sangwoo Lee, Jinyoung Lee, Jungkon Kim, Sunmi Kim, Younglim Kho, Kyungho Choi
A. Chabowski, M. Żendzian-Piotrowska, A. Mikłosz, et al.
C Liu, Y Wang, C Quan, M Yan, J Zhou, C Wang, K Yang
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A Miklosz, A Chabowski, M Zendzian-Piotrowska
"Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish"
L Yu, JCW Lam, Y Guo, et al.
"Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish"
LQ Yu, GF Zhao, M Feng, et al.
Mikłosz A, Łukaszuk B, Chabowski A, et al.
"Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring"
Zhihua H, Yuefei L, Shenghu Z, et al.
"Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae"
S Zhang, X Guo, S Lu, et al.
From: Environmental Pollution
"Embryonic exposure to soil samples from a gangue stacking area induces thyroid hormone disruption in zebrafish"
Fl Yang, Gk Li, N Sang.
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