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MAPT (基因名), Microtubule-associated protein tau (蛋白名), tau_human.
产品名称:

MAPT Antibody

货号:

P1983Rb

商标:
EIAab®
监管等级:
别名:

Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPTL, MTBT1, TAU

序列号:
P10636
反应性:
human,rat
免疫原:
corresponding to a sequence mapping at the 2-251aa of P10636
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
推荐产品:
研究领域:
Neurosciences
  • Human MAPT Polyclonal Antibody
  • Human MAPT Polyclonal Antibody
  • Human MAPT Polyclonal Antibody
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Human MAPT Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human MAPT Polyclonal Antibody
293T lysate was subjected to SDS-Page followed by Western Blot with MAPT antibody at dillution of 1:200 (Observed molecular weight is about 36kDa)
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer?|s Disease using MAPT antibody.
通用注释


亚单元:
Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated (PubMed:15953362). Interacts with FKBP4 (By similarity). Binds to CSNK1D (PubMed:14761950). Interacts with SGK1 (PubMed:16982696). Interacts with EPM2A; the interaction dephosphorylates MAPT at Ser-396 (PubMed:19542233).


功能:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.


亚细胞位置:
Cytoplasm Cytosol Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytoskeleton Cell projection Axon Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.


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