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ZRANB1 (基因名), Ubiquitin thioesterase ZRANB1 (蛋白名), zran1_human.
产品名称:

Human ZRANB1/ Ubiquitin thioesterase ZRANB1 Recombinant Protein
泛素thioesterase ZRANB1

货号:

R2592h

商标:
EIAab®
监管等级:
别名:

TRAF-binding domain-containing protein, Zinc finger Ran-binding domain-containing protein 1, hTrabid, TRABID

序列号:
Q9UGI0
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ZRANB1 Protein
规格 & 价格: cart
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Human ZRANB1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q26.13 by HGNC 10q26.13 by Entrez Gene 10q26.13 by Ensembl
ZRANB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with APC and TRAF6.


功能:
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.


亚细胞位置:
Cytoplasm Nucleus Enriched in punctate localization in the cytoplasm.


该产品尚未在任何出版物中被引用。

[1].
"Isolation and characterization of two novel A20-like proteins."

[2].
"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."

[3].
"Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration."

[4].
"An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains."

[5].
"Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains."

[6].
"Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1."

[7].
"ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer."

[8].
"An Interaction Landscape of Ubiquitin Signaling."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing."
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