首页 > 重组蛋白 > Human ZIC1 Recombinant Protein

ZIC1 (基因名), Zinc finger protein ZIC 1 (蛋白名), zic1_human.

产品名称:

Human ZIC1/ Zinc finger protein ZIC 1 Recombinant Protein

货号:

R2958h

商标:

EIAab^®

监管等级:

RUO

别名:

Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC, ZNF201

序列号:

Q15915

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human ZIC1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 3q24 by HGNC 3q24 by Entrez Gene 3q24 by Ensembl

ZIC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation.

功能:

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

亚细胞位置:

Nucleus Cytoplasm Localizes in the cytoplasm in presence of MDFIC overexpression.

数据库链接

UniGene:

Hs.598590

SMR:

Q15915

STRING:

9606.ENSP00000282928

KEGG:

hsa:7545

MIM:

600470

Uniprot:

Q15915

相关产品

Mouse Zic1 ELISA Kit

Chicken ZIC1 ELISA Kit

Mouse Zic1 CLIA Kit

Chicken ZIC1 CLIA Kit

Mouse Zic1 Protein

序列长度:

447

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

447:

YESSTPPTIV | SPSTDNPTTS | SLSPSSSAVH | HTAGHSALSS | NFNEWYV

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma."

(PMID: 8542595)

[2].

"Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans."

(PMID: 14679585)

[3].

"Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability."

(PMID: 26340333)

[4].

"Expression of ZIC family genes in meningiomas and other brain tumors."

(PMID: 20199689)

[5].

"Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis."

(PMID: 19010793)

[6].

"ZIC1 is downregulated through promoter hypermethylation in gastric cancer."

(PMID: 19135984)

[7].

"Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif."

(PMID: 18515550)

[8].

"ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations."

(PMID: 17936758)

[9].

"The ZIC gene family in development and disease."

(PMID: 15733262)

[10].

"The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription."

(PMID: 12783990)

[1].

人ZIC1重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人ZIC1重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人ZIC1重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人ZIC1重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人ZIC1重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人ZIC1重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人ZIC1重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人ZIC1重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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