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Zfand5 (基因名), AN1-type zinc finger protein 5 (蛋白名), zfan5_mouse.
产品名称:

Mouse Zfand5/ AN1-type zinc finger protein 5 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Zinc finger A20 domain-containing protein 2, Zinc finger protein 216, Za20d2, Zfp216, Znf216

序列号:
O88878
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Mouse Zfand5 Protein
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Mouse Zfand5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain) (By similarity). Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule.


功能:
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。
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