首页 > 重组蛋白 > Human ZC3HAV1 Recombinant Protein

ZC3HAV1 (基因名), Zinc finger CCCH-type antiviral protein 1 (蛋白名), zcchv_human.

产品名称:

Human ZC3HAV1/ Zinc finger CCCH-type antiviral protein 1 Recombinant Protein

货号:

R16041h

商标:

EIAab^®

监管等级:

RUO

别名:

ADP-ribosyltransferase diphtheria toxin-like 13, Inactive Poly [ADP-ribose] polymerase 13, Zinc finger CCCH domain-containing protein 2, Zinc finger antiviral protein, ARTD13, PARP13, ZAP, PRO1677, ZC3HDC2

序列号:

Q7Z2W4

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Epigenetics

规格 & 价格:

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Human ZC3HAV1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 7q34 by HGNC 7q34 by Entrez Gene 7q34 by Ensembl

ZC3HAV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity. Interacts with EXOSC5 (By similarity). Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By similarity). Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A. Interacts with PARN in an RNA-independent manner. Interacts with XRN1 in an RNA-dependent manner. Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an RNA-dependent manner. Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner.

功能:

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

亚细胞位置:

Isoform 2 Cytoplasm

数据库链接

UniGene:

Hs.133512

SMR:

Q7Z2W4

STRING:

9606.ENSP00000242351

KEGG:

hsa:56829

MIM:

607312

Pfam:

PF00644

Uniprot:

Q7Z2W4

相关产品

Mouse Zc3hav1 ELISA Kit

Rat Zc3hav1 ELISA Kit

Mouse Zc3hav1 CLIA Kit

Rat Zc3hav1 CLIA Kit

Mouse Zc3hav1 Protein

序列长度:

902

序列:

仅供参考，详细请咨询（services@eiaab.com）

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917:

PQYVIEYTED | KACV IS

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein."

(PMID: 25635049)

[2].

"Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein."

(PMID: 18225958)

[3].

"Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31."

(PMID: 12851707)

[4].

"Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein."

(PMID: 12215647)

[5].

"Family-wide analysis of poly(ADP-ribose) polymerase activity."

(PMID: 25043379)

[6].

"ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses."

(PMID: 21102435)

[7].

"Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation."

(PMID: 21876179)

[8].

"Expression and RNA-binding of human zinc-finger antiviral protein."

(PMID: 20451500)

[9].

"DEXH-Box protein DHX30 is required for optimal function of the zinc-finger antiviral protein."

(PMID: 21204022)

[10].

"ZAP-mediated mRNA degradation."

(PMID: 18418085)

[1].

人ZC3HAV1重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人ZC3HAV1重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人ZC3HAV1重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人ZC3HAV1重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人ZC3HAV1重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人ZC3HAV1重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人ZC3HAV1重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人ZC3HAV1重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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