ZC3H12A (基因名), Endoribonuclease ZC3H12A (蛋白名), zc12a_human.
产品名称:
Human ZC3H12A/ Endoribonuclease ZC3H12A Recombinant Protein
货号:
R15785h
商标:
EIAab®
监管等级:
别名:
Monocyte chemotactic protein-induced protein 1, Regnase-1, Zinc finger CCCH domain-containing protein 12A, MCP-induced protein 1, Reg1, MCPIP, MCPIP1
序列号:
Q5D1E8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
R&D 技术数据
更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.
基因位点
ZC3H12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
通用注释
亚单元:
(Microbial infection) Oligomerization is necessary for antiviral activity (PubMed:23355615).
功能:
(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).
亚细胞位置:
Nucleus
Cytoplasm
Cytoplasm
P-body
Rough endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasmic granule
Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:22055188, PubMed:26134560).
数据库链接
验证序列:
该产品尚未在任何出版物中被引用。
[1].
"MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation."
[2].
"Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase."
[3].
"A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
[4].
"TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase."
[5].
"Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation."
[6].
"MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation."
[7].
"Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis."
[8].
"MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells."
[10].
"Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression."
[1].
人ZC3H12A重组蛋白是否是无菌的？
蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。
[2].
人ZC3H12A重组蛋白的保存缓冲液是什么？
纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。
[3].
怎样确定人ZC3H12A重组蛋白的浓度？
蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。
[4].
人ZC3H12A重组蛋白蛋白保存条件是怎样的？
蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。
[5].
人ZC3H12A重组蛋白是否可以用于活体实验？
重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。
[6].
人ZC3H12A重组蛋白的保质期是多久？
在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。
[7].
你们蛋白和抗体的报价是怎么样的？
我们将根据你需要的蛋白和抗体的大小进行报价。
[8].
人ZC3H12A重组蛋白是否能够提供蛋白片段？
我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。
[9].
人ZC3H12A重组蛋白的货期或发货时间一般是多长？
具体指标的货期需要确定。最快一周，最长可能一个月。
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