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ZBTB18 (基因名), Zinc finger and BTB domain-containing protein 18 (蛋白名), zbt18_human.
产品名称:

Human ZBTB18/ Zinc finger and BTB domain-containing protein 18 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

58 kDa repressor protein, Transcriptional repressor RP58, Translin-associated zinc finger protein 1, Zinc finger protein 238, Zinc finger protein C2H2-171, TAZ-1, RP58, TAZ1, ZNF238

序列号:
Q99592
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ZBTB18 Protein
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Human ZBTB18 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 1q44 by HGNC 1q44 by Entrez Gene 1q44 by Ensembl
ZBTB18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with DNMT3A.


功能:
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.


亚细胞位置:
Nucleus Associates with condensed chromatin.


该产品尚未在任何出版物中被引用。

[1].
"Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin."

[2].
"The DNA sequence and biological annotation of human chromosome 1."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription."

[5].
"RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression."

[6].
"Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX."

[7].
"C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain."

[8].
"Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain."

[9].
"Further evidence that de novo missense and truncating variants in ZBTB18 cause intellectual disability with variable features."

[10].
"Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU."
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