首页 > 重组蛋白 > Human ZBTB17 Recombinant Protein

ZBTB17 (基因名), Zinc finger and BTB domain-containing protein 17 (蛋白名), zbt17_human.

产品名称:

Human ZBTB17/ Zinc finger and BTB domain-containing protein 17 Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Myc-interacting zinc finger protein 1, Zinc finger protein 151, Zinc finger protein 60, Miz-1, MIZ1, ZNF151, ZNF60

序列号:

Q13105

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

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Human ZBTB17 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 1p36.13 by HGNC 1p36.13 by Entrez Gene 1p36.13 by Ensembl

ZBTB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).

功能:

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.433764

SMR:

Q13105

STRING:

9606.ENSP00000364895

KEGG:

hsa:7709

MIM:

604084

Pfam:

PF00651

Uniprot:

Q13105

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序列长度:

803

序列:

仅供参考，详细请咨询（services@eiaab.com）

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PAE

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain."

(PMID: 17880999)

[2].

"A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells."

(PMID: 14739298)

[3].

"Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1."

(PMID: 12244100)

[4].

"Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc."

(PMID: 9308237)

[5].

"An alternative pathway for gene regulation by Myc."

(PMID: 9312026)

[6].

"Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress."

(PMID: 25245946)

[7].

"A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy."

(PMID: 21459883)

[8].

"ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation."

(PMID: 19901969)

[9].

"Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells."

(PMID: 19419955)

[10].

"Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1."

(PMID: 19164764)

[1].

人ZBTB17重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人ZBTB17重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人ZBTB17重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人ZBTB17重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人ZBTB17重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人ZBTB17重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人ZBTB17重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人ZBTB17重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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