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YME1L1 (基因名), ATP-dependent zinc metalloprotease YME1L1 (蛋白名), ymel1_human.
产品名称:

Human YME1L1/ ATP-dependent zinc metalloprotease YME1L1 Recombinant Protein

货号:

R2968h

商标:
EIAab®
监管等级:
别名:

ATP-dependent metalloprotease FtsH1, Meg-4, Presenilin-associated metalloprotease, YME1-like protein 1, PAMP, UNQ1868/PRO4304, FTSH1, YME1L

序列号:
Q96TA2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human YME1L1 Protein
规格 & 价格: cart
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Human YME1L1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10p12.1 by HGNC 10p12.1 by Entrez Gene 10p12.1 by Ensembl
YME1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Exists in several complexes of 600-1100 kDa.


功能:
Putative ATP-dependent protease. Plays a role in mitochondrial organization and mitochondrial protein metabolism, including degradation of PRELID1 and OPA1 (PubMed:18076378, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).


亚细胞位置:
Mitochondrion inner membrane Mitochondrion


该产品尚未在任何出版物中被引用。

[1].
"YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation."

[2].
"Identification and characterization of YME1L1, a novel paraplegin-related gene."

[3].
"The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits."

[4].
"Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane."

[5].
"Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress."

[6].
"Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation."

[7].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[8].
"Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential."

[9].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."

[10].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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