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XRN2 (基因名), 5'-3' exoribonuclease 2 (蛋白名), xrn2_human.
产品名称:

Human XRN2/ 5'-3' exoribonuclease 2 Recombinant Protein

货号:

R15955h

商标:
EIAab®
监管等级:
别名:

DHM1-like protein, DHP protein

序列号:
Q9H0D6
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human XRN2 Protein
规格 & 价格: cart
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Human XRN2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20p11.22 by HGNC 20p11.22 by Entrez Gene 20p11.22 by Ensembl
XRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with POLR2A and SMN1/SMN2 (PubMed:26700805). Interacts with CDKN2AIP and NKRF (PubMed:24462208). Interacts with CDKN2AIPNL; the interaction is direct (PubMed:26779609).


功能:
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).


亚细胞位置:
Nucleus Nucleolus


该产品尚未在任何出版物中被引用。

[1].
"Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2."

[2].
"A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte."

[3].
"Structural basis and function of XRN2 binding by XTB domains."

[4].
"SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination."

[5].
"The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function."

[6].
"Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination."

[7].
"Pause sites promote transcriptional termination of mammalian RNA polymerase II."

[8].
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."

[9].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

[10].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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