首页 > 重组蛋白 > Human XRCC3 Recombinant Protein

XRCC3 (基因名), DNA repair protein XRCC3 (蛋白名), xrcc3_human.

产品名称:

Human XRCC3/ DNA repair protein XRCC3 Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

X-ray repair cross-complementing protein 3

序列号:

O43542

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

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Human XRCC3 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 14q32.33 by HGNC 14q32.33 by Entrez Gene 14q32.33 by Ensembl

XRCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

功能:

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

亚细胞位置:

Nucleus Cytoplasm Cytoplasm Perinuclear region Mitochondrion Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

数据库链接

UniGene:

Hs.592325

SMR:

O43542

STRING:

9606.ENSP00000343392

KEGG:

hsa:7517

MIM:

114480

Pfam:

PF08423

Uniprot:

O43542

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序列长度:

346

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

346:

LREEEAALGC | PARTLRVLSA | PHLPPSSCSY | TISAEGVRGT | PGTQSH

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Variants in DNA double-strand break repair genes and breast cancer susceptibility."

(PMID: 12023982)

[2].

"A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk."

(PMID: 19915856)

[3].

"Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms."

(PMID: 19177501)

[4].

"XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study."

(PMID: 19330829)

[5].

"Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1)."

(PMID: 19414392)

[6].

"XRCC1 and XRCC3 DNA repair gene polymorphisms in breast cancer women from the Lodz region of Poland."

(PMID: 19886181)

[7].

"Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population?"

(PMID: 19815090)

[8].

"Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer."

(PMID: 19426727)

[9].

"XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer."

(PMID: 17986315)

[10].

"Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan."

(PMID: 18410587)

[1].

人XRCC3重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人XRCC3重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人XRCC3重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人XRCC3重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人XRCC3重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人XRCC3重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人XRCC3重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人XRCC3重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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