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XRCC2 (基因名), DNA repair protein XRCC2 (蛋白名), xrcc2_human.
产品名称:

Human XRCC2/ DNA repair protein XRCC2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

X-ray repair cross-complementing protein 2

序列号:
O43543
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human XRCC2 Protein
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Human XRCC2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 7q36.1 by HGNC 7q36.1 by Entrez Gene 7q36.1 by Ensembl
XRCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.


功能:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.


亚细胞位置:
Nucleus Cytoplasm Cytoskeleton Microtubule organizing center Centrosome


该产品尚未在任何出版物中被引用。

[1].
"Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51."

[2].
"A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility."

[3].
"An investigation on the polymorphisms of two DNA repair genes and susceptibility to ESCC and GCA of high-incidence region in northern China."

[4].
"XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer."

[5].
"Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus."

[6].
"Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan."

[7].
"International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways."

[8].
"Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity."

[9].
"[The association of XRCC2 gene polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in China]."

[10].
"Polymorphisms of DNA repair genes and risk of non-small cell lung cancer."
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