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XPNPEP3 (基因名), Xaa-Pro aminopeptidase 3 (蛋白名), xpp3_human.
产品名称:

Human XPNPEP3/ Xaa-Pro aminopeptidase 3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Aminopeptidase P3, APP3, X-Pro aminopeptidase 3

序列号:
Q9NQH7
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cell Biology
Human XPNPEP3 Protein
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Human XPNPEP3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 22q13.2 by HGNC 22q13.2 by Entrez Gene 22q13.2 by Ensembl
XPNPEP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer (PubMed:28476889). Isoform 1 interacts with TNFRSF1B/TNFR2 (activated) and TRAF2 (PubMed:25609706).


功能:
Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.


亚细胞位置:
Isoform 2 Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy."

[2].
"Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions."

[3].
"Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes."

[4].
"Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2."

[5].
"Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae."

[6].
"A genome annotation-driven approach to cloning the human ORFeome."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"The DNA sequence of human chromosome 22."

[9].
"XPNPEP3 is a novel transcriptional target of canonical Wnt/β-catenin signaling."

[10].
"Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones."
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