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XPO4 (基因名), Exportin-4 (蛋白名), xpo4_human.
产品名称:

Human XPO4/ Exportin-4 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Exp4, KIAA1721

序列号:
Q9C0E2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human XPO4 Protein
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Human XPO4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 13q12.11 by HGNC 13q12.11 by Entrez Gene 13q12.11 by Ensembl
XPO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.


功能:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.


亚细胞位置:
Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm.


该产品尚未在任何出版物中被引用。

[1].
"The mechanism of nuclear export of Smad3 involves exportin 4 and Ran."

[2].
"Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes."

[3].
"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

[4].
"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling."

[5].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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