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WNT3A (基因名), Protein Wnt-3a (蛋白名), wnt3a_human.
产品名称:

Human WNT3A/ Protein Wnt-3a Recombinant Protein
Wnt-3a蛋白

货号:

R2182h

商标:
EIAab®
监管等级:
序列号:
P56704
来源:
E.coli
种属:
Human
标签:
His
序列:
19-352aa
预估分子量:
36.74 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human WNT3A Protein
规格 & 价格: cart
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Human WNT3A Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q42.13 by HGNC 1q42.13 by Entrez Gene 1q42.13 by Ensembl
WNT3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homooligomer; disulfide-linked, leading to inactivation (By similarity). Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.


功能:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region."

[2].
"Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin."

[3].
"Disulfide bond requirements for active Wnt ligands."

[4].
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

[5].
"Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation."

[6].
"APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex."

[7].
"Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."

[8].
"Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation."

[9].
"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men."

[10].
"Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate."
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