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WNT1 (基因名), Proto-oncogene Wnt-1 (蛋白名), wnt1_human.
产品名称:

Human WNT1/ Proto-oncogene Wnt-1 Recombinant Protein
原癌基因Wnt-1

货号:

R1414h

商标:
EIAab®
监管等级:
别名:

Proto-oncogene Int-1 homolog, INT1

序列号:
P04628
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human WNT1 Protein
规格 & 价格: cart
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Human WNT1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12q13.12 by HGNC 12q13.12 by Entrez Gene 12q13.12 by Ensembl
WNT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS.


功能:
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.


亚细胞位置:
Secreted Extracellular space Extracellular matrix


该产品尚未在任何出版物中被引用。

[1].
"The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences."

[2].
"Novel missense loss-of-function mutations of WNT1 in an autosomal recessive Osteogenesis imperfecta patient."

[3].
"Mutations in WNT1 are a cause of osteogenesis imperfecta."

[4].
"Mutations in WNT1 cause different forms of bone fragility."

[5].
"WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta."

[6].
"WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta."

[7].
"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men."

[8].
"Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer."

[9].
"MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation."

[10].
"Expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma."
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