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Wnk2 (基因名), Serine/threonine-protein kinase WNK2 (蛋白名), wnk2_mouse.
产品名称:

Mouse Wnk2/ Serine/threonine-protein kinase WNK2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Protein kinase lysine-deficient 2, Protein kinase with no lysine 2, Kiaa1760

序列号:
Q3UH66
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Wnk2 Protein
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Mouse Wnk2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Forms a complex with the phosphorylated form of STK39 in the brain.


功能:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.


亚细胞位置:
Cytoplasm Cell membrane


该产品尚未在任何出版物中被引用。
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