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WDFY1 (基因名), WD repeat and FYVE domain-containing protein 1 (蛋白名), wdfy1_human.
产品名称:

Human WDFY1/ WD repeat and FYVE domain-containing protein 1 Recombinant Protein

货号:

R8019h

商标:
EIAab®
监管等级:
别名:

FYVE domain-containing protein localized to endosomes 1, Phosphoinositide-binding protein 1, WD40- and FYVE domain-containing protein 1, Zinc finger FYVE domain-containing protein 17, FENS-1, FENS1, KIAA1435, WDF1, ZFYVE17

序列号:
Q8IWB7
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human WDFY1 Protein
规格 & 价格: cart
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Human WDFY1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 2q36.1 by HGNC 2q36.1 by Entrez Gene 2q36.1 by Ensembl
WDFY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds PtdIns3P in vitro with high specificity over other phosphoinositides. Interacts (via WD repeat 2) with tyrosine-phosphorylated TLR3 (via TIR domain) in response to poly(I:C) (PubMed:25736436). Interacts with TICAM1 in response to poly(I:C) (By similarity). Interacts with TLR4 in response to LPS (By similarity).


功能:
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).


亚细胞位置:
Early endosome


该产品尚未在任何出版物中被引用。

[1].
"FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments."

[2].
"WDFY1 mediates TLR3/4 signaling by recruiting TRIF."

[3].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"NRP2 transcriptionally regulates its downstream effector WDFY1."

[8].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[9].
"Panorama of ancient metazoan macromolecular complexes."

[10].
"N-terminome analysis of the human mitochondrial proteome."
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