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VWF (基因名), von Willebrand factor (蛋白名), vwf_human1.
产品名称:

Human VWF/ von Willebrand factor Recombinant Protein
血管假性血友病因子

货号:

R0833h

商标:
EIAab®
监管等级:
别名:

vWF, F8VWF

序列号:
P04275
来源:
E.coli
种属:
Human
标签:
His
序列:
1804-1939aa
预估分子量:
15 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human VWF Protein
规格 & 价格: cart
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Human VWF Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human VWF Protein
Recombinant human VWF protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl
VWF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Multimeric. Interacts with F8.


功能:
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.


亚细胞位置:
Secreted Secreted Extracellular space Extracellular matrix Localized to storage granules.


该产品尚未在任何出版物中被引用。

[1].
"Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group."

[2].
"von Willebrand factor storage and multimerization: 2 independent intracellular processes."

[3].
"A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion."

[4].
"Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor."

[5].
"Substitution of cysteine for phenylalanine 751 in mature von Willebrand factor is a novel candidate mutation in a family with type IIA von Willebrand disease."
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