首页 > 重组蛋白 > Human VTCN1 Recombinant Protein

VTCN1 (基因名), V-set domain-containing T-cell activation inhibitor 1 (蛋白名), vtcn1_human.

产品名称:

Human VTCN1/ V-set domain-containing T-cell activation inhibitor 1 Recombinant Protein
含V-set域T细胞激活抑制因子

货号:

R1079h

商标:

EIAab^®

监管等级:

RUO

别名:

B7 homolog 4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7-H4, UNQ659/PRO1291, B7H4

序列号:

Q7Z7D3

来源:

E.coli

种属:

Human

标签:

His

序列:

90-245aa

预估分子量:

17.16 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human VTCN1 Protein

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产品说明书

数据表:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human VTCN1 gene was determined by 1% Agarose stained with EB.

Recombinant human VTCN1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 1p13.1-p12 by HGNC 1p13.1-p12 by Entrez Gene 1p13.1-p12 by Ensembl

VTCN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

N/A

功能:

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

亚细胞位置:

Cell membrane Single-pass type I membrane protein Expressed at the cell surface. A soluble form has also been detected.

数据库链接

UniGene:

Hs.546434

SMR:

Q7Z7D3

STRING:

9606.ENSP00000358470

KEGG:

hsa:79679

MIM:

608162

Pfam:

PF07686

Uniprot:

Q7Z7D3

相关产品

Mouse Vtcn1 ELISA Kit

序列长度:

282

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

282:

LQLLNSKASL | CVSSFFAISW | ALLPLSPYLM | LK

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Tumor expression of B7-H4 predicts poor survival of patients suVering from gastric cancer"

Jingting Jiang · Yibei Zhu · Changping Wu ·Yueping Shen · Wenxiang Wei · Lujun Chen · Xiao Zheng · Jing Sun · Binfeng Lu · Xueguang Zhang

From: Cancer Immunol Immunother

[1].

"B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."

(PMID: 12818165)

[2].

"Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis."

(PMID: 19116933)

[3].

"B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population."

(PMID: 19903360)

[4].

"B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration."

(PMID: 17509674)

[5].

"B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma."

(PMID: 16606666)

[6].

"B7-H3 and B7-H4 expression in non-small-cell lung cancer."

(PMID: 16782226)

[7].

"B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival."

(PMID: 16798883)

[8].

"Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells."

(PMID: 16785496)

[9].

"The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation."

(PMID: 15878339)

[10].

"B7S1, a novel B7 family member that negatively regulates T cell activation."

(PMID: 12818166)

[1].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人含V-set域T细胞激活抑制因子(VTCN1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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Human VTCN1/ V-set domain-containing T-cell activation inhibitor 1 Recombinant Protein含V-set域T细胞激活抑制因子

R1079h

B7 homolog 4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7-H4, UNQ659/PRO1291, B7H4

Human VTCN1/ V-set domain-containing T-cell activation inhibitor 1 Recombinant Protein
含V-set域T细胞激活抑制因子