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Nae1 (基因名), NEDD8-activating enzyme E1 regulatory subunit (蛋白名), ula1_mouse.
产品名称:

Mouse Nae1/ NEDD8-activating enzyme E1 regulatory subunit Recombinant Protein

货号:

R16099m

商标:
EIAab®
监管等级:
别名:

Amyloid beta precursor protein-binding protein 1, 59 kDa, Amyloid protein-binding protein 1, APP-BP1, Appbp1

序列号:
Q8VBW6
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Mouse Nae1 Protein
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Mouse Nae1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2.


功能:
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.


亚细胞位置:
Cell membrane Colocalizes with APP in lipid rafts.


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